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The machine is running an active database and I am unable/unwilling to do a boot -rOptical drives are not hot-swap devices.
You will need to shut the system down to replace it.
If the system already has an optical drive then there is no need to do any reconfiguration/re-recognition at all. The system won't care whether the original drive or the new drive is present along the same device path. It won't be able to tell any difference.
Think of it this way: If you were replacing the optical drive in your Microsoft Windoze Pee-Cee, would you need to manually have Device Manager re-recognize the new device and then do any special action?