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Drupal needs PDO and won't work with native drivers like OCI8. Contact Andrea Gariboldi, the maintainer of the Oracle adapter for Drupal http://drupal.org/project/oracle. He maintains a number of customer sites running Drupal. He will be able to help you make a decision.
The main PDO_OCI issues with LOBs are: (1) no CLOB support due to original creator being unsure how to handle CLOBs in a portable way across all databases (2) a crash doing multi-row fetches of BLOBs (potential patch in https://bugs.php.net/bug.php?id=57702)
There are other issues with PDO_OCI including no connection pooling and no statement caching. It's a pity the community interest in PDO_OCI hasn't been greater and so no one is maintaining it. Even the core PDO layer isn't getting much attention - there was idle talk recently about moving PHP away from PDO.