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Your requirement look similar to the one posted in this thread:
APEX Interactive Report OnMouseOver Row
So, you can follow Jari's answer (might need some customization in your case).
Otherwise, Apex 4.2 comes with a number of packaged applications like Decision Maker, P-Track*** etc. If you look at their Home page, they have regions built using "PL/SQL Dynamic Content". If you place the mouse over the records in the regions, you will notice a pop-up window with the help content for that record. The list is built using the "detailedStatusList" class and then, the list entries (detailed tool tip) using "detailedListTooltip" class. Finally, they call "detailedStatusListToolTip();" function when the page loads. You can also explore this option as the pop-up comes with a nice UI.