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not able to connect to database using sqlplus

Neo-b Newbie
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Hello All,

I have oracle 10g and 11g installed on AIX 6.1.

Suddenly i am not able to connect to any oracle database facing the below error:

SP2-1503: Unable to initialize Oracle call interface
SP2-0152: ORACLE may not be functioning properly

on both oracle users Oralce 11g and Oracle 10g.

How can I investigate and fix this issue?
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