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It will be out of place upgrade, meaning that 188.8.131.52 software even if its called patch, it is a standalone complete installation of 184.108.40.206 and it cannot be applied on 220.127.116.11 ORACLE_HOME.
Create new ORACLE_HOME installation for 18.104.22.168 and then perform DB upgrade like a normal way, pointing you database to be upgraded to 22.214.171.124 ORACLE_HOME during upgrade.
Pl also see
Important Changes to Oracle Database Patch Sets Starting With 126.96.36.199 [ID 1189783.1]
Things to Consider Before Upgrading to 188.8.131.52 to Avoid Poor Performance or Wrong Results [ID 1392633.1]
Best approach for Oracle database patching sequence to latest/required patchset along with CPU/PSU/any-other-one-off patch [ID 865255.1]