Always give Apex version you are using,
if question related region or page then also mention which theme u are use
in your application
generally in apex 4.2 drag n drop layout removed, so use grid layout property of page item.
means changes in edit page item>>grid layout and manage start new row yes or no?
if generaly you want to keep item on same line then start new row for item y,z,m,q,r,s set to no
and don't change any other page item if page item are in given sequence.
refer example for theme 25 is APEX Theme 25 - Responsive Grid Layout Question: responsive, css, apex, grid