You can install UPK server with WS 2008 R2 SP1 without any issues(may it be standard or enterprise edn.). Oracle database 188.8.131.52 can be used as well.
You can refer the installation guide for version 12.1 incase you have any queries.
You would only need to open the database port(eg 1527) or so on the subject server. There are no other specific port opening requirement on the firewall (port 80 must be open as well, but mostly it is not blocked on servers).
Let us know if you have any further queries or if you have any issues.