So, you want us to research for you for free, eh?
Why not ask support themselves?
Please see (Interoperability Notes EBS 12.0 or 12.1 with RDBMS 12cR1 (Doc ID 1524398.1)).
You may also add (R11i - R12 Database Documentation Resources for E-Business Suite (Doc ID 1072409.1)) to your favourite list. This MOS Doc helps determine what documentation needs to be reviewed and used for E-Business Suite Database for Release 11i and 12.