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Have a look at /etc/sendmail.cf.
Near the top of this file you should see a line starting with "DS". Change this entry to "DSyourmailserver.yourdomain.com".
I believe Halcyon Inc have a more complete solution is you have cash to spend.
Thanks a lot for the reply. I can send emails using sendmail.cf, but in that case I have to go to each and everybox and configure SMTP. Anyways, I was able to fix it by sending mails directly to out exchange server without making changes to sendmail.cf file