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Without using portals?
Google uses RSS feeds to compile their mashups on iGoogle. The positioning of those boxes are managed with AJAX and upon placement are saved into a session so they stay there for each visit after.
Please be a little more clear as to what you are looking for. Yes, it is possible to develop web pages using the technologies you specified to simulate something like iGoogle, so give us some more details on what exactly you're looking for.
Code wouldn't hurt either.