I create [Manager] Resonsibility and check hide [Opportynities screen] in Screen Tab Layout for [Manager] Resonsibility for Siebel Sales Enterprise.
I added user Bob with [Manager] resonsibility.
But user Bob stiil see Opportunities Screen when log on.
User Bob has no other resonsibilities.
I cannot inactivate Opportynities screen because this screen used by other resonsibilities.