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Unit of issue is does not default on requisition. It is used as a default when issuing the item from inventory.
You can create an ASL and on the ASL, you can set the "Purchasing unit of measure". That will get defaulted on the PO. Oracle will do appropriate conversion as well.
e.g. if you primary uom is each and purchasing uom on ASL is dozen.
If you create a req. for 144 each, the PO will come out as 12 Dozen.
Hope this helps,
Thanks Sandeep-worked perfect