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I can't speak for Informatica, but it should be able to connect to the database over the network, so the database server OS wouldn't matter in that case. That is, if Informatica runs on a different Linux machine that runs 32-bit Linux, it can connect over the network to the Exadata database server node. If Informatica requires to run on the database server directly, you'd have to ask them how they can support 64-bit Linux (or you may have to modify or add to your license).