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I dunno which, been asking myself the same question.
After a quick scan on the EM docs I'm going for 12c, the CPU/PSU patch requirments looks to be quite a bit less brain-strain.
12c OEM uses 10.3.5 WLS, patching that component is very different from "the usual" PSU patching.
OMS software is only available with EM 12c. Pre-12c, only EM agent software is available on 64-bit Windows, OMS software is neither available nor planned for 64-bit Windows.
If necessary, see the following MOS note:
Release Schedule of Current Enterprise Manager Releases and Patch Sets (Doc ID 793512.1)
According the certification matrix, currently the following database versions are certified (as managed targets) with EM 12c (220.127.116.11.0):
18.104.22.168.0, 22.214.171.124.0, 126.96.36.199.0, 188.8.131.52.0, 10.2.0.5.0, 10.2.0.4.0, 10.1.0.5.0, 184.108.40.206.0