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oracle 11g R1
known issue on RAC,see MOS doc on this
Client Connection to RAC Intermittently Fails-ORA-12545 TNS: Host or Object Does not Exist [ID 364855.1]
Did you manage to resolve this?
If you didn't i've got a few ideas - it could be an issue with the server end, ie listener/tnsnames config on the server or it could be down to the syntax you've used in your tnsnames entry.
I've dealt with a few of these kinds of issue so post back if its still an issue and I'll try to help you fix it :-)