Just did a little test with the new iOS 6 beta1 and at least the DeviceDemo app seems to work in the simulator. Didn't dear to upgrade my real phone yet, so simulator only so far.
I only had to change the ADF Mobile preferences in JDeveloper to:
iOS Simulator location to /Applications/Xcode45-DP1.app/Contents/Developer/Platforms/iPhoneSimulator.platform/Developer/SDKs/iPhoneSimulator6.0.sdk
xcodebuild directory to /Applications/Xcode45-DP1.app/Contents/Developer/Platforms/iPhoneSimulator.platform/Developer/usr/bin/
Guess not a lot of people will start developing for iOS6 in combination with ADF Mobile just yet, but just wanted to experiment.