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In-place upgrade is possible, but not recommended.
Oracle Database Upgrade Path Reference List [ID 730365.1]
Complete checklist for out-of-place manual upgrade from previous 11.2.0.N version to the latest 11.2.0.N patchset. [ID 1276368.1]
Complete Checklist to Upgrade the Database to 11gR2 using DBUA [ID 870814.1]
Starting from 22.214.171.124, the binaries are released as a patch sets and that are full installation packages which needs to be installed on a separate ORACLE_HOME.
Important Changes to Oracle Database Patch Sets Starting With 126.96.36.199 (Doc ID 1189783.1)
Before upgrading to 188.8.131.52, the recommended patches should be applied to the existing grid environment.
Refer the below document for the recommended patches.
Things to Consider Before Upgrading to 184.108.40.206 Grid Infrastructure/ASM (Doc ID 1363369.1)
In order to install 220.127.116.11, you need to download the Patch 10404530 from MOS.
Refer the below document for the link to download the patchset.
18.104.22.168 Patchset Location For Grid Infrastructure And RDBMS (Doc ID 1362393.1)
Once the patch 10404530 has been downloaded and extracted, start the runInstaller from the staging area and choose the third option "Upgrade Oracle Grid Infrastructure or Oracle Automatic Storage Management" and choose the separate home.
The rest of the proceess will be guieded by the OUI.
Refer the online documentation for the ugprade steps:
Minimizing Downtime During Production Upgrade [ID 478308.1]
Master Note For Oracle Database Upgrades and Migrations [ID 1152016.1]
Different Upgrade Methods For Upgrading Your Database [ID 419550.1]
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