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If you are using these components, you should upgrade them.
How To Upgrade Oracle Warehouse Builder 220.127.116.11 / 18.104.22.168 To 22.214.171.124 / 126.96.36.199 [ID 1225254.1]
Master Note for Oracle Application Express (APEX) Installation [ID 1086415.1]
If you are not using these components, then nothing else needs to be done.
Label Security is not enabled (OPTION OFF) - this implies you are not using this feature.
Information On Installed Database Components and Schemas [ID 472937.1]