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You may run multiple agents on a single host, but it is not a best practice to do so. The upgrade scenario you describe is actually one reason you might want to do this as a temporary strategy. Each agent deployed on a host must upload to a different OMS. The example you cite of multiple agents, all pointing to the same OMS, is not a supportable configuration.
I don't think there's any data on impact or performance since it's not a recommended configuration. If you have host/configuration monitoring enabled on both agents, they will be running the same queries/scripts against the host/inventory, etc. so they will likely have contention at some point. If you monitor the same databases, you will definitely see contention and increased overhead as there will be multiple agents running the same queries. You might also see problems w/ any of the server generated alerts (tablespace, etc) if you change thresholds as the agents send that to the database, and then the database will be out of sync with the other agents.
What exactly is the goal for having multiple agents? Is it short term or long term?