I agree with Jan Marten. It looks like you are using windows 2008 and its a VMware and all this memory is being used by Windows File system Cache.
If you want to disable disk write caching, you can refer to the following steps simply:
Open Computer Management,
select Device Manager,
expand disk drives,
right click the drive which you want to disable write caching,
select Properties, select Policies and choose the appropriate option.\
This should save you some memory. If this does not fix the problem contact your SA to give a deeper look.