Hmm. If there were region Help, what region feature would it be associated with and what action (click, hover, ...) would launch it?
Perhaps you can roll you own using some techniques from https://forums.oracle.com/thread/504767
I would suggest that either clicking on the region title, would bring up a pop up (like page items)
or region help is displayed in the help page (like page help).
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It's a matter or taste. Except for where the information appears, Page Help can include anything one wishes to include about any region on the page. But regarding clicking the Region Title -- not all regions have titles.