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Trying to find out if the following Mixed configuration is certified/supported by Oracle
EBS 220.127.116.11 on RHEL 5 X86
Database Tier - either 18.104.22.168 or 22.214.171.124 on RHEL 5 X86_64
https://support.oracle.com would be the best place to ask. This forum is for Oracle Database install questions.
Perhaps General EBS Discussion would be a better place for your question.
Both are possible -
MOS Doc 730444.1
Check the certification matrix for the same