It all depends on what you want to achieve using multitenant option of 12c database. But yes you can have all your non-prod databases in one database.
So, how does that work with the Apps tier? Do you have multiple versions of the EBS files on the filesystem, one each for each pluggable database?
Managed to get an answer by Googling a bit more.
The multitenant database feature delivered with Oracle Database 12c is not currently certified with any Oracle E-Business Suite version.
This was the situation as of May 2015