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It is recommended to create custom application using adspilce in r12.2.
To create custom application in r12.2 you need to follow below document.
Creating a Custom Application in Oracle E-Business Suite Release 12.2 (Doc ID 1577707.1)
Hotpatch mode is only supported for certain patches, such as NLS and Online Help, or when it is specifically documented in the patch readme.
12.2 - How To Use Online Patching Related To "Hotpatch" Mode, And Is It Possible and/or Supported To Apply Or Abort A Patch Applied To The Run Filesystem Via "Hotpatch" (Instead Of Using ADOP) (Doc ID 2054074.1)