It should not - best to test all critical functionality as part of upgrade testing.
You can start to compare these notes:
Interoperability Notes EBS 12.0 and 12.1 with Database 11gR2 (Doc ID 1058763.1) (for 188.8.131.52)
Interoperability Notes Oracle EBS R12 with Oracle Database 11gR2 (184.108.40.206) (Doc ID 1585578.1)
To check if there is some applications patchs to apply in 220.127.116.11 and not in 18.104.22.168
EBS with 22.214.171.124 will not have much complications, we can safely proceed.
But still you need to check your customization's
Whilst it's likely that there won't be any problems, there of course could be, particularly with customisations that might be using hints or other similar tricks. You should run the upgrade in a test instance with the same specification and then run comparisons between performance of critical processes across the two instances.
there is not much difference between 126.96.36.199 and 188.8.131.52 in terms of performance. We had experience of upgrading to 184.108.40.206 from 220.127.116.11, didn't encounter any performance issue as such.
That seems an odd statement to make? Just because you upgraded your database from one version to another and didn't experience any problems doesn't mean that the next person will. There could be thousands of different factors between your scenario and the OP's, and any one of those could manifest itself as a bug.