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the only option for such a connection would be an ADS interface; however, there's no ADS direct to Booking.com, you can only connect to OPERA Reservation Services (ORS not PMS) and this interface type is in Controlled Availability due to complexity and communication requirements.
So the short answer is, no. For Booking.com you can choose the OHDCS connection or the property can get it through a Channel Manager.
You can check the current list of integrations here: https://docs.oracle.com/cd/E98457_01/docs/Certified%20Third-Party%20Interfaces%20-%20OPERA%205.pdf