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Your question seems to be Jena specific, not related to the Oracle Jena Adaptor. A discussion forum at Jena might be the more appropriate place to ask this question.
Details on the Oracle Jena Adaptor, which allows Jena to be used with Oracle's semantic technology is at: Oracle Jena Adaptor
You can try loading this large OWL into Oracle 11g, using Oracle Jena Adaptor. You can then run Oracle's OWLPrime inference on top of it.