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I think it's from the profile of the user login.
The created by information is stored in the fnd_user table using the user_id. You obtain this value when registering a user
The preparer id is the person/employee, stored in the per_people_f table using the person_id. You obtain this value when adding an employee
This is always the user who will be creating the requistions and must be setup as buyer.
the preparer does not have to be a buyer, but a person in charge of creating PO from the PR must be a buyer.
Pls use this link for PO related queries...