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I have no experience with this Trend anti-virus but I don't know if your looked already the Administration tab in the UM Web Interface, in the Policy sub-tab, in Filter Definitions. There you have a sample of a Virus Scanner with Symantec, maybe that could point you in the right direction.
It's simple - in the settings for smtp_in, you set your relay host to be the host that Trend is running on, just make sure that host knows to send non-local messages outbound.