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Any errors in the database log file? Any invalid objects?
Review the application.log file and see if any errors are reported in the log.
Also, enable trace for JRE and see if it shows any errors when the application hangs again.
Note: 549423.1 - How to enable tracing and logging for Sun JRE (Native Plug-in)
Which version of JRE is deployed on the clients ? There are known issues with certain JRE versions (eg 1.6.0_10). Pl see