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Organization access in inventory responsibility, Handle it from there
Secondly, on Purchase orders and requisitions, items cannot be handled by organization.It will list all items from all ORGS..They can only be handled via personalization
Create a separate reponsibility for each of the 5 Orgs and give org access from Inventory > Set Ups > Organization > Access.
Use Position for users of different Inventory Org Buyers and restrict PO Approval using Approval Groups and Location for the Org assuming they have different locations attached.