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Oracle iSetup is a part of the Oracle E-Business Suite. Hence, you must log in to Oracle E-Business Suite using the self-service login URL and select "Oracle iSetup responsibility". For more details, please refer to [Oracle iSetup User Guide|http://download.oracle.com/docs/cd/B53825_03/current/acrobat/121azug.pdf] and (Note: 395654.1 - Oracle iSetup Documentation Resources, Release 12).
Please make sure you have the mandatory patches applied as per the following documents.
Note: 811040.1 - Isetup List Of Mandatory Patches For R12
Note: 857551.1 - iSetup Mandatory Patches post 12.1.1