Is it possible to trigger workflow to Manger set at Division, BU, Department Level?

Summary

Is it possible to trigger workflow to Manger set at Division, BU, Department Level based on the worker's Department, BU, and Division?

Content

Hello There,

We can set Managers while creating Division, BU, Department, can we use this hierarchy following worker belongs to which department to trigger approval as well?

If yes, then how, if no then what are the other use of setting manager at these levels?

Kind Regards.