If MFA enabled - will REST API and EPM Automate work in same manner?

Summary:

We are using non SSO accounts obviously for REST, if we enable MFA will this continue to work in same manner OR what else should we consider before enabling this?
Content (please ensure you mask any confidential information):

We are using non SSO accounts obviously for REST, if we enable MFA will this continue to work in same manner OR what else should we consider before enabling this and how does this work when enabled in real-time?

Version (include the version you are using, if applicable):

25.02

Code Snippet (add any code snippets that support your topic, if applicable):