Disable components on the item structure VS deleting them

Summary:

Deleting items from Item Structures is a long process and often full of back and forth due to errors. Is there a difference in Item Structure behavior and Work Definition if we disable components on the item structure instead of deleting them?

Content (please ensure you mask any confidential information):

Version (include the version you are using, if applicable):

Code Snippet (add any code snippets that support your topic, if applicable):