Buyer is not able to change the delivery location and inventory Org at PO line

Buyer is not able to change the delivery location and inventory Org at PO line, how to achieve it.

Scenario:

Couple of Procurement requesters raise the PR for for same items (small items in physical size) at different delivery locations, if buyer prepare a PO for different delivery locations it will cost additional transportation changes since each locations are in far way.

Hence buyer raise single PO and wants to use a single delivery locations for supplier, (technically Buyer change the delivery location at PO line), once the item is delivered by suppllier, buyer arrange a single transport to delivery multiple items along with requested item to delivery at requested delivery location. so it will save transporation charges.