Performance when adding around 100 attributes to Data Columns

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I am trying to add an attribute to Data Columns in order to add it to the Manage Columns and search filters in the order list.
Users are requesting that we register everything, but if we do that, we'll have to register 100 attributes.
As an administrator, I am concerned about performance when Index and Keyword Search Enabled are checked for all 100 attributes in Data Columns.
Is there any problem with implementing this setting?