Can we load the data for a security exclusion rule?

Summary:

We are trying to determine the best way to maintain Security exclusion rules we need to build automatically or load in some fashion.

Content (required):

The data which defines a certain population of individuals can vary and based on a large number of values so manually maintaining exclusion rules for this data will be very difficult to maintain. For example. I may have over a thousand department ids which define the people we need to include in the exclusion rule. To add large numbers of departments and more importantly maintain them will be a challenge. Is there the ability to load such a list to update the exclusion rule. Optimally, we would run a report/extract to pull together