Way to exclude some contacts with a specific domain name, but still include others with same domain?

We have a customer that only wants emails sent to their Leadership contacts within the organization, and not others in the org with the same domain name. I know I can create a segment that includes a Filter to exclude contacts with the value of that domain, but is there a way to still send it to some contacts with that domain name?

Or will we have to go through and 'Unsubscribe' each email that we don't want it sent to?