Business Rules getting auto launched multiple times

Summary: Did anyone face issue with business rules getting auto launched multiple times, the behaviour is not very consistent and hard to understand and debug as there are different elements are involved in the request life cycle, like network, proxy, firewall etc.

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Did anyone face issue with business rules getting auto launched multiple times, the behaviour is not very consistent and hard to understand and debug as there are different elements are involved in the request life cycle, like network, proxy, firewall etc. and it happens intermittently adding more complexity.

If so what was causing the issue and what did you do to get over the issue ?