Security Rules

Can Anyone confirm me that,

Creating a Security Rule, restirct the AP invoice Access?

The requirement is  below:

We are using 2 liability Accounts, Normal AP liability Account and Staff Payments Account (a Liability Account)

All employees defined with liability Account as Staff Payments Account.

Now we are using 2 different responsibilities, 1 to enter normal AP invoices and 2 to enter Staff Payment Invoices.

Can we restrict Access to staff payment Invoices from Normal Paybles Responsibility?

Your help and suggession are highly appreciated.

Regards

Jithendra