re-enable accounts after back up

 Not sure this is the right board, please advise where if not...

When we backup production, we have to lock everyone out (via script) to disable accounts.  This works well, but re-enabling accounts via Script method seems to not work for users with multiple responsibilities.  It looks like it does, but it doesn't.  Then we are left with manually enabling each account and each responsibility.

What are we missning?

Thanks in advance