MO: Operating Unit - System Profile - Can it be changed?

Dear Sir/Madam,

(If the community I selected is incorrect, please direct me to the correct community if known.)

My question has to do with the system profile values which can be found under the System Administrator responsibility and then navigate to: Profile > System > Profile: MO: Operating Unit

My company will be changing it's name at the end of June 2012 and in trying to investigate what will need changed, I have the following questions:

1. For system profile option MO: Operating Unit, can its value be changed or will that disrupt all operations?  I ask because I did find some articles where the operating unit was deleted and no one, not even the system administrator was able to log into the application.