Server timeouts - applications hanging

Hi,

We  are a SQL 2005 shop running E1 9.0 / 8.98.3.2.  We have recently started having a problem occuring once a week where users will experience a "processing" screen and nothing will return. 

Here are some of the messages I'm seeing in the log prior to the problem starting:

16 Oct 2012 12:52:57,513[WARN][DMITCHELL][RUNTIME]*ERROR* CallObject@327c327c: COSE#1000 Request timeout: timeout after 120000ms host XXXXX:6015(1229) SocID:52202 PID:7664 BSFN:F4114EndDocument user:DMITCHELL Env:JPD900

16 Oct 2012 12:55:58,004[WARN][DMITCHELL][RUNTIME]*ERROR* CallObject@71a271a2: COSE#1000 Request timeout: timeout after 120000ms host XXXXX:6015(1229) SocID:52202 PID:7664 BSFN:ProcessF41021WFRecords user:DMITCHELL Env:JPD900

16 Oct 2012 13:00:39,438[WARN][DMITCHELL][RUNTIME]*ERROR* CallObject@746e746e: COSE#1000 Request timeout: timeout after 120000ms host XXXXX:6015(1229) SocID:52202 PID:7664 BSFN:F3016GetKanbanMaster user:DMITCHELL Env:JPD900