Configuration of AME for Invoice Approval in different Operating Units

Dear Experts,

We have a requirement of Invoice Approval for our client.
SO I configured Invoice approval using AME for attribute SUPPLIER_INVOICE_AMOUNT.
and i was able to send the Invoice for approval by setting up 'Supervisor level'
action type. This invoice approval is working fine for one operating unit.

But our client is having many number of Operating Units, how to configure
the AME for Invoice approval in such a way that Invoice raised in different
operating units should go to different approval list in diff Operating units.

Can we setup different approver groups with respect to diff operating units?.