Restrict Price list access to specific users

What is the best method to allow specific users to place orders using only a specific price list

Currentky we dont have QP: Security Profile enabled. The value is No.

Should we turn this to Y and set priveleges to all the users?

Set the following profile options

QP: Security Control = 'ON'

QP: Security Default Maintain Privilege =

QP: Security Default View Only Privilege =

What are the implications for turning the QP security profile ON? Do we need to create the privelege access for pricelist and modifiers for all the users?

Thanks