Price List Functionality

We currently use the horizontal CRM On Demand product.  We do not use orders, instead using opportunities, and only internal users have access to our system, no "partners" which I assume are users outside our company.  My question is this.  One of my sales divisions has price lists specific to a customer.  So say the customer is Intel.  The standard MSRP for hypothetical product "A" is $1000, but for Intel their price is "$500".  Our internal sales team is creating the opportunity and adding the opportunity product revenue records.  Can price lists be used in this case such that when