Handling huge PO data in Oracle EBS :

Presently we are in the development stage of the implementation project: In our business to fulfill sales order lines, we are planning to using back to back PO functionality. The volume of back to back POs/ASNs/PO Receipts that are expected to be created per week are approx 50,000 to 1,00,000.

Below are my question on what can be done so that we can support/handle this much huge volume:

1. What can be done so that Oracle Purchasing can handle this much huge volume?

2. What can be done so that the standard programs like PO out from communication, Receiving Transaction Processor and other standard program can handle this much volume.