Expense Reports only routing to Supervisor/Delegated Approver on Employee Profile

When an Expense report is submitted, it is routed only to either the Supervisor or the Delegated Approver that exists on the employee's profile.  This is despite the fact that Supervisor is inactive on the Transaction Definition, and HR Supervisor is unchecked on Installation Options.  My understanding is that this happens when the system can't determine who to route the report to, but I have Approval Type, Profile, Assignment, Routing and Summary Approval defined. Not really sure what I'm missing.