Locator Control

We recently went live with some new inventory organizations. The existing inventory organization is an expense organization, but we have created some new additional inventory organizations where inventory is tracked. The original setup had locator control set at the item master level. If we would change to organization level would this cause us any issues? We still have some new organizations to roll out so we have not finished and would like to set the locators, but we don't want to live to regret the decision. Any feedback would be helpful.